The role of MbtH - like proteins in the adenylation of tyrosine 1
نویسندگان
چکیده
Background: L-tyrosine adenylation is a key step in aminocoumarin antibiotic and vancomycin biosynthesis. Results: Several, but not all tyrosine-adenylating enzymes require MbtH-like proteins for activity, forming heterotetrameric complexes. A single L→M mutation creates an MbtH-independent enzyme. Conclusion and Significance: MbtH-like proteins are essential tools in the combinatorial biosynthesis of antibiotics.
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